/* ==========================================================================
   Piperazine.com — Design System
   Palette matches Vetr (orange / white) with a professional medical feel
   ========================================================================== */
:root{
  --orange:#EA5406;
  --orange-2:#FF7A1A;
  --orange-soft:#FFF1E8;
  --orange-tint:#FFE3D0;
  --ink:#152238;        /* deep navy text */
  --ink-2:#3A4A63;      /* secondary text */
  --muted:#6B7A90;
  --line:#E7EBF1;
  --bg:#ffffff;
  --bg-soft:#F7F9FC;
  --bg-soft-2:#F1F5FA;
  --white:#ffffff;
  --green:#1F9D6B;
  --amber:#B9770B;
  --red:#C23B33;
  --shadow-sm:0 1px 2px rgba(21,34,56,.06),0 1px 3px rgba(21,34,56,.08);
  --shadow:0 4px 16px rgba(21,34,56,.08);
  --shadow-lg:0 18px 48px rgba(21,34,56,.14);
  --radius:14px;
  --radius-sm:10px;
  --radius-lg:22px;
  --wrap:1160px;
  --font:'Poppins',-apple-system,BlinkMacSystemFont,'Segoe UI',Roboto,Arial,sans-serif;
}
*{box-sizing:border-box}
html{scroll-behavior:smooth}
body{
  margin:0;font-family:var(--font);color:var(--ink);background:var(--bg);
  line-height:1.65;font-size:17px;-webkit-font-smoothing:antialiased;
}
img{max-width:100%;display:block}
a{color:var(--orange);text-decoration:none}
a:hover{text-decoration:underline}
h1,h2,h3,h4{line-height:1.18;color:var(--ink);margin:0 0 .5em;font-weight:700;letter-spacing:-.02em}
h1{font-size:2.55rem}
h2{font-size:1.95rem}
h3{font-size:1.28rem}
p{margin:0 0 1.1em}
.wrap{max-width:var(--wrap);margin:0 auto;padding:0 22px}
.narrow{max-width:820px}
section{padding:76px 0}
.eyebrow{display:inline-block;font-size:.8rem;font-weight:700;letter-spacing:1.6px;
  text-transform:uppercase;color:var(--orange);margin-bottom:14px}
.lead{font-size:1.2rem;color:var(--ink-2)}
.center{text-align:center}
.bg-soft{background:var(--bg-soft)}
.bg-ink{background:var(--ink);color:#DCE4EF}
.bg-ink h2,.bg-ink h3{color:#fff}

/* ---------- Buttons ---------- */
.btn{display:inline-flex;align-items:center;gap:9px;font-weight:600;font-size:1rem;
  padding:14px 26px;border-radius:999px;border:2px solid transparent;cursor:pointer;
  transition:.18s ease;text-decoration:none;line-height:1}
.btn:hover{text-decoration:none;transform:translateY(-2px)}
.btn-primary{background:var(--orange);color:#fff;box-shadow:0 8px 20px rgba(234,84,6,.28)}
.btn-primary:hover{background:#d24b04;box-shadow:0 12px 26px rgba(234,84,6,.34)}
.btn-ghost{background:#fff;color:var(--ink);border-color:var(--line)}
.btn-ghost:hover{border-color:var(--orange);color:var(--orange)}
.btn-lg{padding:17px 34px;font-size:1.08rem}
.btn-white{background:#fff;color:var(--orange)}
.btn-arrow::after{content:"→";font-weight:700}

/* ---------- Header ---------- */
.site-header{position:sticky;top:0;z-index:50;background:rgba(255,255,255,.92);
  backdrop-filter:saturate(180%) blur(10px);border-bottom:1px solid var(--line)}
.nav{display:flex;align-items:center;justify-content:space-between;height:90px;gap:20px}
.brand img{height:50px;width:auto;flex:none}
.nav-links{display:flex;align-items:center;gap:26px;list-style:none;margin:0;padding:0}
.nav-links a{color:var(--ink-2);font-weight:600;font-size:1.02rem;white-space:nowrap;display:inline-flex;align-items:center}
.nav-links a:hover{color:var(--orange);text-decoration:none}
.caret{font-size:.6em;margin-left:6px;color:var(--muted);position:relative;top:1px;transition:.16s}
.has-drop:hover .caret{color:var(--orange);transform:translateY(1px)}
.nav-cta{display:flex;align-items:center;gap:14px}
.nav-cta .btn{padding:12px 22px;font-size:1rem;white-space:nowrap}
.has-drop{position:relative}
.drop{position:absolute;top:120%;left:50%;transform:translateX(-50%) translateY(6px);
  background:#fff;border:1px solid var(--line);border-radius:14px;box-shadow:var(--shadow-lg);
  padding:10px;min-width:212px;opacity:0;visibility:hidden;transition:.16s;display:grid;gap:2px}
.has-drop:hover .drop,.has-drop:focus-within .drop{opacity:1;visibility:visible;transform:translateX(-50%) translateY(0)}
.drop a{display:block;padding:11px 16px;border-radius:9px;color:var(--ink-2);font-size:1rem}
.drop a:hover{background:var(--orange-soft);color:var(--orange);text-decoration:none}
.menu-btn{display:none;background:none;border:0;cursor:pointer;padding:6px}
.menu-btn span{display:block;width:24px;height:2.5px;background:var(--ink);margin:5px 0;border-radius:2px;transition:.2s}

/* ---------- Hero ---------- */
.hero{position:relative;overflow:hidden;background:
  radial-gradient(1200px 600px at 82% -8%,var(--orange-soft),transparent 60%),
  linear-gradient(180deg,#fff, #FCFDFE)}
.hero-grid{display:grid;grid-template-columns:1.05fr .95fr;gap:52px;align-items:center;padding:70px 0 60px}
.hero h1{font-size:3rem;margin-bottom:.35em}
.hero h1 span{color:var(--orange)}
.hero p.lead{margin-bottom:1.6em}
.hero-cta{display:flex;gap:14px;flex-wrap:wrap}
.trust-row{display:flex;gap:26px;flex-wrap:wrap;margin-top:30px;color:var(--muted);font-size:.9rem}
.trust-row b{color:var(--ink)}
.trust-row span{display:flex;align-items:center;gap:8px}
.tick{color:var(--green);font-weight:800}

/* ---------- Cards / grids ---------- */
.grid{display:grid;gap:22px}
.g2{grid-template-columns:repeat(2,1fr)}
.g3{grid-template-columns:repeat(3,1fr)}
.g4{grid-template-columns:repeat(4,1fr)}
.card{background:#fff;border:1px solid var(--line);border-radius:var(--radius);
  padding:26px;box-shadow:var(--shadow-sm);transition:.18s;height:100%}
a.card:hover{transform:translateY(-4px);box-shadow:var(--shadow-lg);border-color:var(--orange-tint);text-decoration:none}
.card h3{margin-bottom:.35em}
.card p{color:var(--ink-2);margin-bottom:.6em;font-size:.98rem}
.card .more{font-weight:600;color:var(--orange);font-size:.95rem}
.ico{width:52px;height:52px;border-radius:13px;display:grid;place-items:center;
  background:var(--orange-soft);margin-bottom:16px;font-size:26px}
.species-ico{font-size:30px}

/* ---------- Calculator ---------- */
.calc{background:#fff;border:1px solid var(--line);border-radius:var(--radius-lg);
  box-shadow:var(--shadow-lg);overflow:hidden}
.calc-head{background:linear-gradient(120deg,var(--orange),var(--orange-2));color:#fff;padding:22px 28px}
.calc-head h3{color:#fff;margin:0;font-size:1.25rem;display:flex;align-items:center;gap:10px}
.calc-head p{margin:.3em 0 0;color:#FFE9DC;font-size:.9rem}
.calc-body{padding:26px 28px}
.field{margin-bottom:18px}
.field label{display:block;font-weight:600;font-size:.92rem;margin-bottom:7px;color:var(--ink)}
.field .hint{font-weight:400;color:var(--muted);font-size:.82rem}
.control{display:flex;gap:10px}
select,input[type=number]{width:100%;padding:13px 14px;border:1.5px solid var(--line);
  border-radius:var(--radius-sm);font-family:inherit;font-size:1rem;color:var(--ink);background:#fff;transition:.15s}
select:focus,input:focus{outline:none;border-color:var(--orange);box-shadow:0 0 0 3px rgba(234,84,6,.14)}
.unit-toggle{display:inline-flex;background:var(--bg-soft-2);border-radius:999px;padding:4px;gap:2px}
.unit-toggle button{border:0;background:none;padding:9px 16px;border-radius:999px;font-weight:600;
  cursor:pointer;color:var(--muted);font-family:inherit;font-size:.9rem}
.unit-toggle button.active{background:#fff;color:var(--orange);box-shadow:var(--shadow-sm)}
.calc-result{margin-top:6px;border-radius:var(--radius);background:var(--orange-soft);
  border:1px solid var(--orange-tint);padding:22px;display:none}
.calc-result.show{display:block;animation:fade .3s ease}
@keyframes fade{from{opacity:0;transform:translateY(6px)}to{opacity:1;transform:none}}
.dose-big{font-size:2rem;font-weight:800;color:var(--orange);line-height:1.1}
.dose-big small{font-size:1rem;color:var(--ink-2);font-weight:600}
.result-row{display:flex;justify-content:space-between;gap:14px;padding:9px 0;border-bottom:1px dashed var(--orange-tint);font-size:.94rem}
.result-row:last-child{border-bottom:0}
.result-row b{color:var(--ink)}
.calc-note{font-size:.82rem;color:var(--ink-2);margin-top:14px;background:#fff;border-radius:10px;padding:12px 14px;border:1px solid var(--line)}
.calc-disc{font-size:.78rem;color:var(--muted);margin-top:12px}
.err{color:var(--red);font-size:.86rem;margin-top:6px;display:none}
.err.show{display:block}

/* ---------- Callouts ---------- */
.callout{border-left:4px solid var(--orange);background:var(--orange-soft);
  border-radius:0 12px 12px 0;padding:16px 20px;margin:22px 0}
.callout.warn{border-color:var(--amber);background:#FFF7E8}
.callout.danger{border-color:var(--red);background:#FDF0EF}
.callout p:last-child{margin-bottom:0}
.callout strong{color:var(--ink)}

/* ---------- Article / prose ---------- */
.prose h2{margin-top:1.6em}
.prose h3{margin-top:1.4em}
.prose ul,.prose ol{margin:0 0 1.2em;padding-left:1.3em}
.prose li{margin-bottom:.5em;color:var(--ink-2)}
.prose table{width:100%;border-collapse:collapse;margin:1.2em 0;font-size:.95rem;
  border:1px solid var(--line);border-radius:12px;overflow:hidden}
.prose th{background:var(--bg-soft-2);text-align:left;padding:12px 14px;font-size:.86rem;
  text-transform:uppercase;letter-spacing:.5px;color:var(--ink-2)}
.prose td{padding:12px 14px;border-top:1px solid var(--line);color:var(--ink-2)}
.prose tr:nth-child(even) td{background:var(--bg-soft)}

/* breadcrumb + page head */
.page-head{background:
  radial-gradient(900px 400px at 88% -20%,var(--orange-soft),transparent 60%),var(--bg-soft);
  border-bottom:1px solid var(--line);padding:38px 0 42px}
.crumb{font-size:.84rem;color:var(--muted);margin-bottom:14px}
.crumb a{color:var(--muted)}.crumb a:hover{color:var(--orange)}
.page-head h1{margin-bottom:.25em}
.page-head p{color:var(--ink-2);max-width:720px;margin:0}

/* CTA band */
.cta-band{background:linear-gradient(120deg,#152238,#1E3252);color:#fff;border-radius:var(--radius-lg);
  padding:44px 46px;display:flex;align-items:center;justify-content:space-between;gap:30px;flex-wrap:wrap}
.cta-band h2{color:#fff;margin:0 0 .3em}
.cta-band p{color:#B9C6D8;margin:0;max-width:560px}
.vetr-pill{display:inline-flex;align-items:center;gap:8px;background:rgba(255,122,26,.16);
  color:#FFB07A;border-radius:999px;padding:5px 13px;font-size:.8rem;font-weight:600;margin-bottom:14px}

/* stats */
.stats{display:grid;grid-template-columns:repeat(4,1fr);gap:18px;text-align:center}
.stat b{display:block;font-size:2.1rem;color:var(--orange);font-weight:800;line-height:1}
.stat span{color:var(--muted);font-size:.88rem}

/* FAQ */
.faq details{border:1px solid var(--line);border-radius:12px;margin-bottom:12px;background:#fff;overflow:hidden}
.faq summary{cursor:pointer;padding:18px 22px;font-weight:600;list-style:none;display:flex;
  justify-content:space-between;align-items:center;gap:16px;color:var(--ink)}
.faq summary::-webkit-details-marker{display:none}
.faq summary::after{content:"+";font-size:1.5rem;color:var(--orange);font-weight:400;transition:.2s}
.faq details[open] summary::after{transform:rotate(45deg)}
.faq details[open] summary{border-bottom:1px solid var(--line)}
.faq .ans{padding:16px 22px 20px;color:var(--ink-2)}
.faq .ans p:last-child{margin-bottom:0}

/* ---------- Footer ---------- */
.site-footer{background:#101B2E;color:#9FB0C6;padding:60px 0 28px;font-size:.92rem}
.foot-grid{display:grid;grid-template-columns:1.4fr 1fr 1fr 1fr;gap:34px;margin-bottom:40px}
.site-footer h4{color:#fff;font-size:.82rem;letter-spacing:1.2px;text-transform:uppercase;margin-bottom:16px}
.site-footer ul{list-style:none;margin:0;padding:0}
.site-footer li{margin-bottom:10px}
.site-footer a{color:#9FB0C6}.site-footer a:hover{color:#fff;text-decoration:none}
.foot-brand img{height:36px;margin-bottom:14px;filter:brightness(0) invert(1)}
.foot-brand p{color:#7C8DA5;max-width:280px;font-size:.9rem}
.foot-bottom{border-top:1px solid #22334C;padding-top:22px;display:flex;justify-content:space-between;
  gap:16px;flex-wrap:wrap;color:#6E809A;font-size:.84rem}
.foot-disc{background:#0B1424;border-top:1px solid #22334C;padding:16px 0;color:#63748D;font-size:.78rem}

/* utilities */
.mt0{margin-top:0}.mb0{margin-bottom:0}
.pill{display:inline-block;background:var(--orange-soft);color:var(--orange);font-weight:600;
  font-size:.78rem;padding:4px 11px;border-radius:999px;margin-bottom:10px}
.chip{display:inline-block;background:var(--bg-soft-2);color:var(--ink-2);border-radius:999px;
  padding:6px 13px;font-size:.85rem;margin:0 6px 8px 0}

/* ---------- Responsive ---------- */
@media(max-width:980px){
  h1{font-size:2.1rem}.hero h1{font-size:2.3rem}h2{font-size:1.6rem}
  .hero-grid{grid-template-columns:1fr;gap:34px;padding:44px 0}
  .g3,.g4,.foot-grid,.stats{grid-template-columns:repeat(2,1fr)}
  .cta-band{padding:34px 28px}
  section{padding:56px 0}
  .nav-links,.nav-cta .btn-ghost{display:none}
  .menu-btn{display:block}
  .nav-links.open{display:flex;position:absolute;top:90px;left:0;right:0;flex-direction:column;
    background:#fff;border-bottom:1px solid var(--line);padding:16px 22px;gap:4px;box-shadow:var(--shadow)}
  .nav-links.open li{width:100%}
  .nav-links.open a{display:block;padding:11px 0}
  .nav-links.open .drop{position:static;opacity:1;visibility:visible;transform:none;box-shadow:none;
    border:0;padding:0 0 8px 14px;min-width:0}
}
@media(max-width:560px){
  body{font-size:16px}
  .g2,.g3,.g4,.foot-grid,.stats{grid-template-columns:1fr}
  .cta-band{flex-direction:column;align-items:flex-start}
  .dose-big{font-size:1.6rem}
  section{padding:44px 0}
  .nav{height:72px}
  .brand img{height:42px}
  .nav-links.open{top:72px}
  .nav-cta .btn-primary{padding:10px 16px;font-size:.9rem}
}
@media(max-width:400px){
  .nav-cta .btn-primary{display:none}
}